Apoptotic killing of HIV-1-infected macrophages is subverted by the viral envelope glycoprotein.
Viruses have evolved strategies Cardigans to protect infected cells from apoptotic clearance.We present evidence that HIV-1 possesses a mechanism to protect infected macrophages from the apoptotic effects of the death ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand).In HIV-1-infected macrophages, the viral envelope protein ind